WebMay 8, 2024 · Atorvastatin is the most common cause of clinically significant liver injury in this drug class. We report a case of severe, asymptomatic liver injury in a hepatocellular pattern in a 71-year-old man occurring within 3 months of switching from simvastatin to high-intensity atorvastatin therapy. Hepatitis improved rapidly with cessation of ... WebNov 17, 2024 · The most common signs and symptoms of rhabdomyolysis include: Severe muscle aching throughout the entire body. Muscle weakness. Dark or cola-colored urine. The higher the dose of statins, the higher the risk of rhabdomyolysis becomes. The risk also increases if certain drugs — including cyclosporine (Sandimmune) and gemfibrozil (Lopid ...
Lipitor (atorvastatin) vs. Crestor (rosuvastatin) - MedicineNet
WebAtorvastatin has an average rating of 4.2 out of 10 from a total of 284 ratings on Drugs.com. 28% of reviewers reported a positive effect, while 57% reported a negative effect. Simvastatin has an average rating of 4.8 out of 10 from a total of 130 ratings on Drugs.com. 31% of reviewers reported a positive effect, while 50% reported a negative ... Web• Do not start simvastatin 80 mg because of an increased risk of myopathy. • The maximum safe dose of simvastatin is 40 mg. • Risk for simvastatin-induced myopathy at doses of 80 mg is greatest in the first year of therapy. • Simvastatin 80 mg may be continued only if simvastatin has been taken for longer than 12 months and the patient elite gas agency jorhat
New restrictions, contraindications, and dose limitations for Zocor
WebNov 6, 2008 · The term myopathy is often used to include the entire spectrum of muscle related adverse events (as in this article), but other definitions are common, especially when the term is used in clinical trials. ... the average incidence per 10 000 person years for monotherapy with atorvastatin, pravastatin, or simvastatin was 0.44 (0.20 to 0.84) and ... WebOne trial also compared rosuvastatin with simvastatin and atorvastatin in very elderly patients. The trial enrolled a selected 73 cases over 80 years old (81.7 ± 2.1 years, (80–86 years) with CHD, who were divided into three groups according to the different statin drugs: 27 in the simvastatin group (20 mg/day), 32 in the atorvastatin group ... WebSince advanced age (≥65 years) is a predisposing factor for myopathy, atorvastatin should be prescribed with caution in the elderly. 8.6 Hepatic Impairment . ... (8.2%) in the … elite gas and plumbing