Glycerol-3-phosphate acyltransferase 3-like
WebFeb 5, 2024 · The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. …
Glycerol-3-phosphate acyltransferase 3-like
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WebFour homologous isoforms of glycerol-3-phosphate acyltransferase (GPAT), each the product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3-phosphate and long-chain acyl-CoA. This step initiates the synthesis of all the glycerolipids and evidence from gain-of-functi … WebNov 18, 2024 · Triacylglycerol (TAG) is one of the most abundant lipids in the epidermis, and TAG synthesis and hydrolysis are reported to be related to acyl-ceramide (Cer) synthesis and corneocyte lipid envelope (CLE) formation [1,2,3].The systemic lack of diacylglycerol O-acyltransferase 2 (Dgat2), the gene for TAG synthesis, leads to an impaired …
WebIntroduction. Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first and committed step in the de novo glycerolipid synthesis pathway, which is the synthesis of … Microsomal GPAT4, originally named AGPAT6, was classified to be a member of the AGPAT family due to the high homology of its amino acid sequence with those of AGPAT1 and 2. However, it was found that AGPAT6 exhibited GPAT activity, but not AGPAT activity, and thus it was renamed as GPAT447. With 66% … See more During lactation, GPAT4 mRNA is highly expressed in mammary gland epithelium, but not in the surrounding adipocytes of breast tissue. The … See more In GPAT4-deficient mice fed with a normal chow diet, GPAT4 activity was significantly reduced in the liver, brown adipose tissue, and mammary gland (45, 65, and ~90%, respectively) as compared to the control group, but was … See more GPAT4 is also widely expressed postnatally in spermatocytes and around spermatids in mice testis, which might make a significant … See more Like mitochondrial GPAT1, GPAT4 is also associated with hepatic lipid accumulation and contributes to the development of insulin resistance. … See more
WebEsterifies acyl-group from acyl-ACP to the sn-2 position of glycerol-3-phosphate, a step in cutin biosynthesis. 1 publication. Catalytic activity an acyl-CoA + sn-glycerol 3 … WebThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. By similarity Sequence …
WebGlycerol-3-phosphate 2-O-acyltransferase ( EC 2.3.1.198, sn-2-glycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate O-acyltransferase) is an enzyme with systematic name acyl-CoA:sn-glycerol 3-phosphate 2-O-acyltransferase. [1] This enzyme catalyses the following chemical reaction
WebApr 20, 2011 · Although glycerol-3-phosphate acyltransferase-1 (GPAT1) esterifies glycerol-3-phosphate to form LPA, an intermediate in the de novo synthesis of glycerolipids, it has been assumed that LPA ... diamond water by asaWebWe also detected two novel mutations (Val67Met and Leu19Arg) in children with syndromic forms of diabetes like Berardinelli Seip syndrome [1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)] and Fanconi Bickel … cistern\\u0027s 36WebThis enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor. Catalytic activity a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA EC:2.3.1.51 ( UniProtKB ENZYME Rhea) Source: Rhea 19709 Hide Rhea reaction a 1-acyl- sn -glycero-3-phosphate CHEBI:57970 zoom + an acyl-CoA CHEBI:58342 zoom = cistern\u0027s 3fWebIn enzymology, a glycerol-3-phosphate O-acyltransferase (EC 2.3.1.15) is an enzyme that catalyzes the chemical reaction acyl-CoA + sn-glycerol 3-phosphate ⇌ … cistern\u0027s 38WebGene ID: 118461045, updated on 14-Aug-2024. Summary Other designations. 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like cistern\u0027s 3lWebAGPAT3 is a member of a family of 1-acyl-sn-glycerol 3-phosphate acyltransferases ( EC 2.3.1.51 ), also known as lysophosphatidic acid acyltransferases, that catalyze the acylation of lysophosphatidic acid to phosphatidic acid, the precursor of all glycerolipids (summary by Lu et al., 2005 ). cistern\u0027s 39WebGlycerol-3-Phosphate Acyltransferase 1 Deficiency in ob/ob Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity Angela A. Wendel, 1Lei O. Li, Yue Li,1 Gary W. Cline,2 Gerald I. Shulman,2,3 and Rosalind A. Coleman1 OBJECTIVE—Hepatic steatosis is strongly associated with in- sulin resistance, but a … diamond water back snake