WebJohn Gordon’s Post John Gordon WebJan 7, 2010 · More than 150 pigmentation-related genes have been identified, including glycoprotein nonmetastatic melanoma protein b (GPNMB). A recent proteomics analysis revealed that GPNMB is localized in melanosomes, and GPNMB is a membrane-bound glycoprotein that shows high homology with a well-known melanosomal structural …

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WebDec 8, 2024 · A glycoprotein is a type of protein molecule that has had a carbohydrate attached to it. The process either occurs during protein translation or as a posttranslational modification in a process called … WebAug 30, 2024 · Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type-I transmembrane glycoprotein first identified in a melanoma cell line. GPNMB augments bone mineral deposition by stimulating osteoblast differentiation. Aside from its anabolic function in the bone, emerging evidence suggests that GPNMB has anti-inflammatory … movie big little lies cast

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All animal experiments were conducted in compliance with the guidelines which was reviewed by the Institutional Animal Care and Use Committee of Niigata University and Juntendo University, and this study is approved by the Institutional Animal Care and Use Committee of Niigata University and … See more SA-β-gal activity was examined as described previously9. Briefly, cells were fixed with 0.25% Glutaraldehyde in PBS at room temperature for 15 min, then washed with PBS 1 time, … See more Human umbilical vein endothelial cells (HUVECs) and human aortic endothelial cells (HAECs) were purchased from Lonza and cultured according to the manufacturer’s instructions. Replicative senescent cells were … See more Mice were housed individually to monitor their health status. For the vascular reactivity assay, mice were placed on the HFD (CLEA) for 8 weeks (from 4 to 12 weeks of age). Then mice were anesthetized and … See more For doxorubicin-induced premature senescent cells, cells were resuspended at 2.5 × 103 cells per well to a 96-well black wall/clear bottom plate (Corning) with the culture medium containing 1/500 volume of Incucyte … See more WebThe glycoprotein nonmetastatic melanoma protein B (GPNMB) functions as a membrane-binding surface receptor, a melanosome-associated protein, a soluble ligand, or an adhesion molecule; it is highly ... WebGlycoprotein nonmetastatic melanoma protein B (GPNMB) is a type I transmembrane protein reported to have neuroprotective effects in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). We investigated whether GPNMB is also neuroprotective against brain ischemia-reperfusion injury (IRI). Focal … movie big jake with john wayne